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RNAi screening identifies KAT8 as a key molecule important for cancer cell survival.
|Title||RNAi screening identifies KAT8 as a key molecule important for cancer cell survival.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Zhang S, Liu X, Zhang Y, Cheng Y, Li Y|
|Journal||International journal of clinical and experimental pathology|
Histone acetyltransferases (HATs) regulate many critical cancer events, including transcriptional regulation of oncogene and tumor suppressors, chromatin structure and DNA damage response. Abnormal expression of HATs has been reported in a number of cancers. However, cellular functions of HATs in cancer and molecular mechanisms remain largely unclear. Here, we performed a lentiviral vector-mediated RNAi screen to systematically address the function of HATs in lung cancer cell growth and viability. We identified 8 HATs genes involved in A549 cell viability. Further experiments showed that KAT8 regulates G2/M cell cycle arrest through AKT/ERK-cyclin D1 signaling. Moreover, KAT8 inhibition led to p53 induction and subsequently reduced bcl-2 expression. Our results demonstrate an important role of KAT8 in cancer and suggest that KAT8 could be a novel cancer therapeutic target.
|Alternate Journal||Int J Clin Exp Pathol|