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Rhodium(III)-catalyzed redox-neutral coupling of N-phenoxyacetamides and alkynes with tunable selectivity.
|Title||Rhodium(III)-catalyzed redox-neutral coupling of N-phenoxyacetamides and alkynes with tunable selectivity.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Liu G, Shen Y, Zhou Z, Lu X|
|Journal||Angewandte Chemie (International ed. in English)|
|Date Published||2013 Jun 3|
Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed CH functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp*=C5 Me5 ).
|Alternate Journal||Angew. Chem. Int. Ed. Engl.|