Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor.

TitleReversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor.
Publication TypeJournal Article
Year of Publication2013
AuthorsYin Q, Shen J, Zhang Z, Yu H, Li Y
JournalAdvanced drug delivery reviews
Volume65
Issue13-14
Pagination1699-715
Date Published2013 Nov 30
Abstract

Multidrug resistance (MDR) is a major obstacle to successful cancer therapy, especially for chemotherapy. The new drug delivery system (DDS) provides promising approaches to reverse MDR, for which the poor cellular uptake and insufficient intracellular drug release remain rate-limiting steps for reaching the drug concentration level within the therapeutic window. Stimulus-coupled drug delivery can control the drug-releasing pattern temporally and spatially, and improve the accumulation of chemotherapeutic agents at targeting sites. In this review, the applications of DDS which is responsive to different types of stimuli in MDR cancer therapy is introduced, and the design, construction, stimuli-sensitivity and the effect to reverse MDR of the stimuli-responsive DDS are discussed.

DOI10.1074/jbc.M113.510966
Alternate JournalAdv. Drug Deliv. Rev.