Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.

TitleRetinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.
Publication TypeJournal Article
Year of Publication2011
AuthorsSoto I, Pease ME, Son JL, Shi X, Quigley HA, Marsh-Armstrong N
JournalInvestigative ophthalmology & visual science
Volume52
Issue1
Pagination434-41
Date Published2011 Jan
Abstract

Previous analyses of the DBA/2J mouse glaucoma model show a sectorial degeneration pattern suggestive of an optic nerve head insult. In addition, there are large numbers of retinal ganglion cells (RGCs) that cannot be retrogradely labeled but maintain RGC gene expression, and many of these have somatic phosphorylated neurofilament labeling. Here the authors further elucidate these features of glaucomatous degeneration in a rat ocular hypertension model.

DOI10.1097/BRS.0b013e3181e7d675
Alternate JournalInvest. Ophthalmol. Vis. Sci.