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Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.
| Title | Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Soto I, Pease ME, Son JL, Shi X, Quigley HA, Marsh-Armstrong N |
| Journal | Investigative ophthalmology & visual science |
| Volume | 52 |
| Issue | 1 |
| Pagination | 434-41 |
| Date Published | 2011 Jan |
| Abstract | Previous analyses of the DBA/2J mouse glaucoma model show a sectorial degeneration pattern suggestive of an optic nerve head insult. In addition, there are large numbers of retinal ganglion cells (RGCs) that cannot be retrogradely labeled but maintain RGC gene expression, and many of these have somatic phosphorylated neurofilament labeling. Here the authors further elucidate these features of glaucomatous degeneration in a rat ocular hypertension model. |
| DOI | 10.1097/BRS.0b013e3181e7d675 |
| Alternate Journal | Invest. Ophthalmol. Vis. Sci. |
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