Responses of the antioxidant system in QGY-7701 cells to the cytotoxicity and apoptosis induced by 1-octyl-3-methylimidazolium chloride.

TitleResponses of the antioxidant system in QGY-7701 cells to the cytotoxicity and apoptosis induced by 1-octyl-3-methylimidazolium chloride.
Publication TypeJournal Article
Year of Publication2013
AuthorsJing C, Li X, Zhang J, Wang J
JournalJournal of biochemical and molecular toxicology
Volume27
Issue6
Pagination330-6
Date Published2013 Jun
Abstract

This study aims to evaluate the cytotoxicity and responses of the cellular antioxidant system of 1-octyl-3-methylimidazolium chloride ([C8 mim][Cl]) on human hepatocarcinoma QGY-7701 cells. The results show that [C8 mim][Cl] can inhibit QGY-7701 cell growth and decrease their viabilities in a dose-dependent manner. The results also reveal that [C8 mim][Cl] exposure can induce apoptosis in the [C8 mim][Cl]-treated QGY-7701 cells. In addition, the results of biochemical assays show that [C8 mim][Cl] exposure causes overproduction of reactive oxygen species (ROS), inhibits superoxide dismutase (SOD) and catalase (CAT) activities, decreases reduced glutathione (GSH) content, and increases the cellular malondialdehyde (MDA) level. These results suggest that ROS-mediated oxidative stress may be responsible for the apoptosis induced by [C8 mim][Cl] in QGY-7701 cells.

DOI10.1371/annotation/f4d7cc29-9ea5-46cf-ad41-17728176df6d
Alternate JournalJ. Biochem. Mol. Toxicol.