Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.

TitleUp-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.
Publication TypeJournal Article
Year of Publication2013
AuthorsHuang L, Huang M, Li Y-H, Li R-M, Zeng Y, Kuang S-Y, Zhang L, Wang Y-T, Bi H-C
JournalJournal of ethnopharmacology
Volume148
Issue2
Pagination596-602
Date Published2013 Jul 9
Abstract

Qianhu, the dried roots of Peucedanum praeruptorum DUNN (Umbelliferae), is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin D (PD) is one of the major active constituents of Peucedanum praeruptorum Dunn (Qianhu). The Pregnane X receptor (PXR) is an orphan nuclear receptor and plays a pivotal role in the activation of human cytochrome P450 3A4 (CYP3A4) gene.

DOI10.3109/08820139.2013.801986
Alternate JournalJ Ethnopharmacol