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Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.
|Title||Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Huang L, Huang M, Li Y-H, Li R-M, Zeng Y, Kuang S-Y, Zhang L, Wang Y-T, Bi H-C|
|Journal||Journal of ethnopharmacology|
|Date Published||2013 Jul 9|
Qianhu, the dried roots of Peucedanum praeruptorum DUNN (Umbelliferae), is a well-known traditional Chinese medicinal herb which was officially listed in the Chinese Pharmacopoeia. Praeruptorin D (PD) is one of the major active constituents of Peucedanum praeruptorum Dunn (Qianhu). The Pregnane X receptor (PXR) is an orphan nuclear receptor and plays a pivotal role in the activation of human cytochrome P450 3A4 (CYP3A4) gene.
|Alternate Journal||J Ethnopharmacol|