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Real-time dynamic optical imaging of ACC-M tumor cells killed by HSV-tk/ACV system.
|Title||Real-time dynamic optical imaging of ACC-M tumor cells killed by HSV-tk/ACV system.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Xiong T, Li Y, Li Z, Xie X, Lu L|
|Journal||Journal of nanoscience and nanotechnology|
|Date Published||2013 Jan|
HSV-tk/ACV induced and killed human adenoid cystic carcinoma cell (ACC-M) in vivo and in vitro, which were observed through optical imaging and green fluorescence protein (GFP) tagging technique. ACC-M was transfected with TK-GFP, and the single clone cell ACC-M-TK-GFP was selected by G418. With fluorescent stereomicroscope, whole-body fluorescent imaging system and fluorescent microscope, we could observe ACV treated ACC-M-TK-GFP cells in cell level and nude mice. The therapies of tumor were visualized clearly with optical imaging. This study proves that optical imaging is a very good approach for studying the effect of HSV-tk/ACV on the ACC-M tumor cells and decreasing the amount of vessel about tumors cell. Optical imaging will become a visual groundwork for monitoring tumor growth and evaluating in vivo curative effect of antitumor drugs.
|Alternate Journal||J Nanosci Nanotechnol|