Rapamycin sensitizes glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and up-regulation and activation of glucocorticoid receptor.

TitleRapamycin sensitizes glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and up-regulation and activation of glucocorticoid receptor.
Publication TypeJournal Article
Year of Publication2013
AuthorsGuo X, Zhou CY, Li Q, Gao J, Zhu YP, Gu L, Ma ZG
JournalBiomedical and environmental sciences : BES
Volume26
Issue5
Pagination371-81
Date Published2013 May
Abstract

To explore the role of glucocorticoid (GC) receptor (GR) in rapamycin's reversion of GC resistance in human GC-resistant T-acute lymphoblastic leukemia (ALL) CEM-C1 cells.

DOI10.1074/jbc.M113.510966
Alternate JournalBiomed. Environ. Sci.