Quantitative MRI of articular cartilage and its clinical applications.

TitleQuantitative MRI of articular cartilage and its clinical applications.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Majumdar S
JournalJournal of magnetic resonance imaging : JMRI
Volume38
Issue5
Pagination991-1008
Date Published2013 Nov
Abstract

Cartilage is one of the most essential tissues for healthy joint function and is compromised in degenerative and traumatic joint diseases. There have been tremendous advances during the past decade using quantitative MRI techniques as a noninvasive tool for evaluating cartilage, with a focus on assessing cartilage degeneration during osteoarthritis (OA). In this review, after a brief overview of cartilage composition and degeneration, we discuss techniques that grade and quantify morphologic changes as well as the techniques that quantify changes in the extracellular matrix. The basic principles, in vivo applications, advantages, and challenges for each technique are discussed. Recent studies using the OA Initiative (OAI) data are also summarized. Quantitative MRI provides noninvasive measures of cartilage degeneration at the earliest stages of joint degeneration, which is essential for efforts toward prevention and early intervention in OA.

DOI10.1371/journal.pone.0077156
Alternate JournalJ Magn Reson Imaging