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Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T(1) in the rotating frame.
|Title||Quantitative magnetic resonance imaging assessment of cerebral ischemia in rat using on-resonance T(1) in the rotating frame.|
|Publication Type||Journal Article|
|Year of Publication||1999|
|Authors||Gröhn OH, Lukkarinen JA, Silvennoinen MJ, Pitkänen A, van Zijl PC, Kauppinen RA|
|Journal||Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine|
|Date Published||1999 Aug|
Sensitivity of T(1) in the rotating frame (T(1rho)) to both transient cerebral ischemia and cortical hypoperfusion was studied in rats. T(1rho) is believed to probe water in close contact with macromolecules, revealing water spins with restricted rotational mobility relative to bulk water. It is shown that T(1rho) increases within minutes of occlusion, thereby demonstrating it as a new, sensitive indicator of ischemia. After reperfusion at 90 minutes of middle cerebral artery occlusion, T(1rho) remains elevated or increases in tissue destined to neuronal damage but returns to the normal level if no neuronal damage develops within 24 hours. T(1rho) determined during the first 2 hours of reperfusion shows a significant positive correlation with the ultimate neuronal damage score. However, T(1rho) is not affected by acute hypoperfusion. These data show that, by combining three magnetic resonance imaging coefficients, i.e. T(1rho), T(2), and diffusion, viable hypoperfused areas that do not develop neuronal damage within 24 hours can be distinguished correctly from tissue already destined for neuronal damage. Magn Reson Med 42:268-276, 1999.
|Alternate Journal||Magn Reson Med|