Protective effect of erythropoietin in neonatal hypoxic ischemia in mice.

TitleProtective effect of erythropoietin in neonatal hypoxic ischemia in mice.
Publication TypeJournal Article
Year of Publication2003
AuthorsMatsushita H, Johnston MV, Lange MS, Wilson MA
JournalNeuroreport
Volume14
Issue13
Pagination1757-61
Date Published2003 Sep 15
Abstract

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

Alternate JournalNeuroreport