Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.

TitleProspective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids.
Publication TypeJournal Article
Year of Publication2013
AuthorsCondon MB, Ashby D, Pepper RJ, Cook TH, Levy JB, Griffith M, Cairns TD, Lightstone L
JournalAnnals of the rheumatic diseases
Volume72
Issue8
Pagination1280-6
Date Published2013 Aug
Abstract

Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus (SLE). All current treatment regimens include oral steroids, which are associated with severe adverse events and long-term damage. We have piloted a steroid-avoiding protocol (rituxilup) for the treatment of biopsy-proven active International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III, IV, or class V LN.

DOI10.1371/journal.pone.0075620
Alternate JournalAnn. Rheum. Dis.