Prospective evaluation of term neonate brain damage following preceding hypoxic sentinel events using enhanced T2* weighted angiography (eSWAN).

TitleProspective evaluation of term neonate brain damage following preceding hypoxic sentinel events using enhanced T2* weighted angiography (eSWAN).
Publication TypeJournal Article
Year of Publication2013
AuthorsLing X, Huang L, Liu G, Tang W, Li X, Li B, Wu H, Liu S
JournalThe International journal of neuroscience
Volume123
Issue12
Pagination837-46
Date Published2013 Dec
Abstract

Purpose: To evaluate the brain damage of term neonates with evidence of a preceding hypoxic sentinel event using eSWAN prospectively. Methods: The study was approved by the institutional research ethics committee. Among the neonates who were examined during the first 8 days after birth with conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and eSWAN, 39 neonates with a preceding acute hypoxic sentinel event were divided into two groups: the hypoxic ischaemic encephalopathy (HIE) group and the high-risk group. Twenty-five neonates were normal control subjects. Conventional MRI, DWI, and T2* and R2* maps from eSWAN were assessed. T2* and R2* values from T2* and R2* maps were calculated in predefined regions in the HIE and high-risk groups and then compared with those in control subjects. Results: The neonates in the HIE and high-risk groups showed a high percentage of cerebral oedema and periventricular white-matter (PWM) lesions. Cerebral oedema and haemorrhagic lesions of PWM were more highly visible on the T2* map compared with conventional MRI: cerebral oedema was illustrated as a high T2* area and haemorrhagic lesions had a significantly lower T2* on the T2* map. Lower R2* values of lentiform nuclei (LN) and a higher T2* and lower R2* of frontal white matter (FWM) were found in neonates in the HIE group relative to those of normal controls. The T2* value of LN in the high-risk group was higher than that of the normal controls. Conclusions: The T2* map from eSWAN is useful in detecting cerebral oedema and haemorrhagic lesions of PWM in neonates. The measurement of T2* and R2* values is helpful in assessing the LN and FWM damage in neonates following a hypoxic sentinel event.

DOI10.1105/tpc.113.112417
Alternate JournalInt. J. Neurosci.