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Population-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial.
| Title | Population-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | McGovern RA, Thielen A, Portsmouth S, Mo T, Dong W, Woods CK, Zhong X, Brumme CJ, Chapman D, Lewis M, James I, Heera J, Valdez H, Harrigan RP |
| Journal | Journal of acquired immune deficiency syndromes (1999) |
| Volume | 61 |
| Issue | 3 |
| Pagination | 279-86 |
| Date Published | 2012 Nov 1 |
| Abstract | MERIT was a randomized trial comparing maraviroc (MVC) + Combivir versus efavirenz (EFV) + Combivir in drug-naive patients screened as having R5 HIV-1 by the original Trofile assay (OTA). We retrospectively evaluated treatment response after rescreening for viral tropism using population-based V3-loop sequencing. |
| DOI | 10.1542/peds.2012-0852 |
| Alternate Journal | J. Acquir. Immune Defic. Syndr. |
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