Population-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial.

TitlePopulation-based sequencing of the V3-loop can predict the virological response to maraviroc in treatment-naive patients of the MERIT trial.
Publication TypeJournal Article
Year of Publication2012
AuthorsMcGovern RA, Thielen A, Portsmouth S, Mo T, Dong W, Woods CK, Zhong X, Brumme CJ, Chapman D, Lewis M, James I, Heera J, Valdez H, Harrigan RP
JournalJournal of acquired immune deficiency syndromes (1999)
Volume61
Issue3
Pagination279-86
Date Published2012 Nov 1
Abstract

MERIT was a randomized trial comparing maraviroc (MVC) + Combivir versus efavirenz (EFV) + Combivir in drug-naive patients screened as having R5 HIV-1 by the original Trofile assay (OTA). We retrospectively evaluated treatment response after rescreening for viral tropism using population-based V3-loop sequencing.

DOI10.1155/2013/326986
Alternate JournalJ. Acquir. Immune Defic. Syndr.