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Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.
|Title||Polymorphism of ORM1 is associated with the pharmacokinetics of telmisartan.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Chen W-Q, Shu Y, Li Q, Xu L-Y, Roederer MW, Fan L, Wu L-X, He F-Z, Luo J-Q, Tan Z-R, He Y-J, Zhou H-H, Chen X, Zhang W|
The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP change after taking 40 mg telmisartan in 48 healthy Chinese males.
|Alternate Journal||PLoS ONE|