Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.

TitlePoly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.
Publication TypeJournal Article
Year of Publication2002
AuthorsGoto S, Xue R, Sugo N, Sawada M, Blizzard KK, Poitras MF, Johns DC, Dawson TM, Dawson VL, Crain BJ, Traystman RJ, Mori S, Hurn PD
JournalStroke; a journal of cerebral circulation
Volume33
Issue4
Pagination1101-6
Date Published2002 Apr
Abstract

Poly(ADP-ribose) polymerase (PARP-1; Enzyme Commission 2.4.30) is a nuclear DNA repair enzyme that mediates early neuronal ischemic injury. Using novel 3-dimensional, fast spin-echo-based diffusion-weighted imaging, we compared acute (21 hours) and long-term (3 days) ischemic volume after middle cerebral artery (MCA) occlusion in PARP-1-null mutants (PARP-/-) versus genetically matched wild-type mice (WT mice). PARP-/- mice were also treated with viral transfection of wild-type PARP-1 to determine whether protection from MCA occlusion is lost with restoration of the gene product.

Alternate JournalStroke