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Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery.
| Title | Poly(ADP-ribose) polymerase impairs early and long-term experimental stroke recovery. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Goto S, Xue R, Sugo N, Sawada M, Blizzard KK, Poitras MF, Johns DC, Dawson TM, Dawson VL, Crain BJ, Traystman RJ, Mori S, Hurn PD |
| Journal | Stroke; a journal of cerebral circulation |
| Volume | 33 |
| Issue | 4 |
| Pagination | 1101-6 |
| Date Published | 2002 Apr |
| Abstract | Poly(ADP-ribose) polymerase (PARP-1; Enzyme Commission 2.4.30) is a nuclear DNA repair enzyme that mediates early neuronal ischemic injury. Using novel 3-dimensional, fast spin-echo-based diffusion-weighted imaging, we compared acute (21 hours) and long-term (3 days) ischemic volume after middle cerebral artery (MCA) occlusion in PARP-1-null mutants (PARP-/-) versus genetically matched wild-type mice (WT mice). PARP-/- mice were also treated with viral transfection of wild-type PARP-1 to determine whether protection from MCA occlusion is lost with restoration of the gene product. |
| Alternate Journal | Stroke |
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