Platinum(II) complexes containing aminophosphonate esters: Synthesis, characterization, cytotoxicity and action mechanism.

TitlePlatinum(II) complexes containing aminophosphonate esters: Synthesis, characterization, cytotoxicity and action mechanism.
Publication TypeJournal Article
Year of Publication2013
AuthorsHuang K-B, Chen Z-F, Liu Y-C, Li Z-Q, Wei J-H, Wang M, Xie X-L, Liang H
JournalEuropean journal of medicinal chemistry
Volume64
Pagination554-61
Date Published2013 Jun
Abstract

New platinum(II) complexes containing aminophosphonate ester were synthesized and fully characterized, which were found to possess better solubility in both organic solvents and water than cisplatin. These platinum(II) complexes exhibited considerable cytotoxicity against tumor cells MG-63, SK-OV-3, HepG2, BEL-7404 and low cytotoxicity to normal human liver cells HL-7702. Their antitumor activities were achieved through the induction of cell apoptosis and the cell cycle arrest at G1 phase. The electrophoretic mobility studies and CD spectral analysis revealed that the binding mode of complex 6 to DNA might be different from that of cisplatin.

DOI10.3978/j.issn.2225-319X.2013.06.03
Alternate JournalEur J Med Chem