Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss.

TitlePlasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss.
Publication TypeJournal Article
Year of Publication2010
AuthorsMielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG
JournalAlzheimer's & dementia : the journal of the Alzheimer's Association
Volume6
Issue5
Pagination378-85
Date Published2010 Sep
Abstract

A blood-based biomarker of Alzheimer's disease (AD) would be superior to cerebrospinal fluid (CSF) and neuroimaging measures in terms of cost, invasiveness, and feasibility for repeated measures. We previously reported that blood ceramides varied in relation to timing of memory impairment in a population-based study. The present objective was to examine whether plasma ceramides varied by AD severity in a well-characterized clinic sample and were associated with cognitive decline and hippocampal volume loss over 1 year.

DOI10.1097/BRS.0b013e3181e7d675
Alternate JournalAlzheimers Dement