PKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.

TitlePKG II inhibits EGF/EGFR-induced migration of gastric cancer cells.
Publication TypeJournal Article
Year of Publication2013
AuthorsJiang L, Lan T, Chen Y, Sang J, Li Y, Wu M, Tao Y, Wang Y, Qian H, Gu L
JournalPloS one
Volume8
Issue4
Paginatione61674
Date Published2013
Abstract

Our previous research results showed that Type II cGMP dependent protein kinase (PKG II) could block the activation of epidermal growth factor receptor (EGFR) and consequently inhibit the proliferation and the related MAPK/ERK-mediated signal transduction of gastric cancer cell line BGC-823, suggesting that PKG II might inhibit other EGFR-triggered signal transduction pathways and related biological activities of gastric cancer cells. This paper was designed to investigate the potential inhibition of PKG II on EGF/EGFR-induced migration activity and the related signal transduction pathways.

DOI10.1242/bio.20133988
Alternate JournalPLoS ONE