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Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.
|Title||Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Caparrelli DJ, Cattaneo SM, Bethea BT, Shake JG, Eberhart C, Blue ME, Marbán E, Johnston MV, Baumgartner WA, Gott VL|
|Journal||The Annals of thoracic surgery|
|Pagination||838-44; discussion 844-5|
|Date Published||2002 Sep|
Pharmacological openers of mitochondrial ATP-sensitive potassium (mitoKATP) channels have been shown to mimic ischemic preconditioning (IPC) in both the brain and myocardium. We hypothesized that similar endogenous mechanisms exist in the spinal cord and that diazoxide, a potent mitoKATP opener, could reduce neurologic injury after aortic cross-clamping in a model of spinal cord ischemia.
|Alternate Journal||Ann. Thorac. Surg.|