Pharmacokinetics and Safety of Duloxetine Enteric-coated Tablets in Chinese Healthy Volunteers: A Randomized, Open-label, Single- and Multiple-dose Study.

TitlePharmacokinetics and Safety of Duloxetine Enteric-coated Tablets in Chinese Healthy Volunteers: A Randomized, Open-label, Single- and Multiple-dose Study.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi H, Li T, Li Y, Shen Y
JournalClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
Volume11
Issue1
Pagination28-33
Date Published2013 Apr
Abstract

Duloxetine hydrochloride is a selective serotonin (5-hydroxytryptamine) and norepinephrine reuptake inhibitor. It is approved for effective treatment for major depressive disorder. The pharmacokinetics (PK) of duloxetine has been studied, but few pharmacokinetics properties in Chinese subjects are available. This study explored the dose proportionality and determined duloxetine levels in human plasma by comparing the PK properties after administration of single or multiple doses in healthy volunteers.

DOI10.1039/c3an01929b
Alternate JournalClin Psychopharmacol Neurosci