Passive Immunization Against Marinobufagenin Attenuates Renal Fibrosis and Improves Renal Function in Experimental Renal Disease.

TitlePassive Immunization Against Marinobufagenin Attenuates Renal Fibrosis and Improves Renal Function in Experimental Renal Disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsHaller ST, Drummond CA, Yan Y, Liu J, Tian J, Malhotra D, Shapiro JI
JournalAmerican journal of hypertension
Date Published2013 Sep 6
Abstract

We have shown that the cardiotonic steroid marinobufagenin (MBG) is elevated in clinical and experimental renal disease, and significantly contributes to the development of experimental uremic cardiomyopathy induced by removal of five-sixths of the kidney (5/6 nephrectomy; PNx) in the rat. We have demonstrated that both active and passive immunization against MBG with an anti-MBG monoclonal antibody (mAb 3E9) significantly attenuated cardiac fibrosis following PNx. In the present study we sought to determine whether the use of mAb 3E9 could improve renal function following PNx.

DOI10.1080/17441730.2013.807597
Alternate JournalAm. J. Hypertens.