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PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy.
|Title||PARP-1 regulates resistance of pancreatic cancer to TRAIL therapy.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Yuan K, Sun Y, Zhou T, McDonald J, Chen Y|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2013 Sep 1|
Activating extrinsic apoptotic pathways targeting death receptors (DR) using agonistic antibodies or TNF-related apoptosis-inducing ligand (TRAIL) is promising for cancer therapy. However, most pancreatic cancers are resistant to TRAIL therapy. The present studies aimed to identify combination therapies that enhance the efficacy of TRAIL therapy and to investigate the underlying mechanisms.
|Alternate Journal||Clin. Cancer Res.|