Parental report of the early development of children with regressive autism: the delays-plus-regression phenotype.

TitleParental report of the early development of children with regressive autism: the delays-plus-regression phenotype.
Publication TypeJournal Article
Year of Publication2005
AuthorsOzonoff S, Williams BJ, Landa R
JournalAutism : the international journal of research and practice
Volume9
Issue5
Pagination461-86
Date Published2005 Dec
Abstract

Most children with autism demonstrate developmental abnormalities in their first year, whereas others display regression after mostly normal development. Few studies have examined the early development of the latter group. This study developed a retrospective measure, the Early Development Questionnaire (EDQ), to collect specific, parent-reported information about development in the first 18 months. Based on their EDQ scores, 60 children with autism between the ages of 3 and 9 were divided into three groups: an early onset group (n = 29), a definite regression group (n = 23), and a heterogeneous mixed group (n = 8). Significant differences in early social development were found between the early onset and regression groups. However, over 50 percent of the children who experienced a regression demonstrated some early social deficits during the first year of life, long before regression and the apparent onset of autism. This group, tentatively labeled 'delays-plus-regression', deserves further study.

DOI10.3174/ajnr.A3505
Alternate JournalAutism