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A novel multi-component reaction to imidazo[4,5-g]-quinazolines.
|Title||A novel multi-component reaction to imidazo[4,5-g]-quinazolines.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li L, Zhang Q, Liu B, Liu G|
|Journal||Molecules (Basel, Switzerland)|
The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff's base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.