A novel multi-component reaction to imidazo[4,5-g]-quinazolines.

TitleA novel multi-component reaction to imidazo[4,5-g]-quinazolines.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi L, Zhang Q, Liu B, Liu G
JournalMolecules (Basel, Switzerland)
Volume18
Issue5
Pagination5697-705
Date Published2013
Abstract

The trace impurities discovered after extended storage of a 5-amino- benzimidazole library were determined as imidazo[4,5-g]quinazoline derivatives by extensive spectroscopic data analysis. The formation of this highly aromatic heterocyclic ring involved a novel multi-component reaction, using which several novel compounds were prepared. Its mechanism was deduced as a cascade of chemical transformations, including the formation of a Schiff's base, intramolecular hetero-Diels-Alder reaction, defluorination and dehydrogenation.

DOI10.1007/s00264-013-1920-7
Alternate JournalMolecules