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A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
|Title||A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Hoyt SB, London C, Abbadie C, Felix JP, Garcia ML, Jochnowitz N, Karanam BV, Li X, Lyons KA, McGowan E, Priest BT, Smith MHM, Warren VA, Thomas-Fowlkes BS, Kaczorowski GJ, Duffy JL|
|Journal||Bioorganic & medicinal chemistry letters|
|Date Published||2013 Jun 15|
A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.
|Alternate Journal||Bioorg. Med. Chem. Lett.|