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North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype.
|Title||North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Zumaya-Estrada FA, Messenger LA, Lopez-Ordonez T, Lewis MD, Flores-Lopez CA, Martínez-Ibarra AJ, Pennington PM, Cordon-Rosales C, Carrasco HV, Segovia M, Miles MA, Llewellyn MS|
|Journal||Parasites & vectors|
Trypanosoma cruzi, the agent of Chagas disease, is currently recognized as a complex of six lineages or Discrete Typing Units (DTU): TcI-TcVI. Recent studies have identified a divergent group within TcI - TcI(DOM). TcI(DOM). is associated with a significant proportion of human TcI infections in South America, largely absent from local wild mammals and vectors, yet closely related to sylvatic strains in North/Central America. Our aim was to examine hypotheses describing the origin of the TcI(DOM) genotype. We propose two possible scenarios: an emergence of TcI(DOM) in northern South America as a sister group of North American strain progenitors and dispersal among domestic transmission cycles, or an origin in North America, prior to dispersal back into South American domestic cycles. To provide further insight we undertook high resolution nuclear and mitochondrial genotyping of multiple Central American strains (from areas of México and Guatemala) and included them in an analysis with other published data.
|Alternate Journal||Parasit Vectors|