The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass.

TitleThe Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass.
Publication TypeJournal Article
Year of Publication2013
AuthorsThompson JP, Serrano-Gomez A, McDonald J, Ladak N, Bowrey S, Lambert DG
JournalPloS one
Volume8
Issue10
Paginatione76682
Date Published2013
Abstract

Nociceptin/Orphanin FQ (N/OFQ) is a non-classical endogenous opioid peptide that modulates immune function in vitro. Its importance in inflammation and human sepsis is unknown. The objectives of this study were to determine the relationship between N/OFQ, transcripts for its precursor (pre-pro-N/OFQ [ppNOC]) and receptor (NOP), inflammatory markers and clinical outcomes in patients undergoing cardiopulmonary bypass and with sepsis.

DOI10.1371/journal.pone.0077156
Alternate JournalPLoS ONE