Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids.

TitleNickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X-J, Zhang J-L, Geng Y, Jin Z
JournalThe Journal of organic chemistry
Volume78
Issue10
Pagination5078-84
Date Published2013 May 17
Abstract

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups.

DOI10.1128/genomeA.00236-13
Alternate JournalJ. Org. Chem.