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Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids.
|Title||Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X-J, Zhang J-L, Geng Y, Jin Z|
|Journal||The Journal of organic chemistry|
|Date Published||2013 May 17|
Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazine-6-yl ethers, in which aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl2(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups.
|Alternate Journal||J. Org. Chem.|