A new gene for Tourette's syndrome: a window into causal mechanisms?

TitleA new gene for Tourette's syndrome: a window into causal mechanisms?
Publication TypeJournal Article
Year of Publication2006
AuthorsGrados MA, Walkup JT
JournalTrends in genetics : TIG
Volume22
Issue6
Pagination291-3
Date Published2006 Jun
Abstract

Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.

Alternate JournalTrends Genet.