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A new gene for Tourette's syndrome: a window into causal mechanisms?
|Title||A new gene for Tourette's syndrome: a window into causal mechanisms?|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||Grados MA, Walkup JT|
|Journal||Trends in genetics : TIG|
|Date Published||2006 Jun|
Gilles de la Tourette syndrome (GTS) is a neurodevelopmental disorder characterized by impairing motor-vocal tics. Locating genetic loci by associating the phenotype with DNA translocations, inversions, gain or losses, State et al. identified SLITRK1 as a candidate gene in an individual with GTS and inv(13) (q31.1; q33.1). This gene was also associated with abnormal axonal-dendritic development in embryonic mouse cells. Although SLITRK1 is not a major causal gene for GTS, it can shed light on our understanding of the gene-based neural correlates of this disease.
|Alternate Journal||Trends Genet.|