New azole antagonists with high affinity for the P2Y(1) receptor.

TitleNew azole antagonists with high affinity for the P2Y(1) receptor.
Publication TypeJournal Article
Year of Publication2013
AuthorsRuel R, L'heureux A, Thibeault C, Daris J-P, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PYS
JournalBioorganic & medicinal chemistry letters
Volume23
Issue12
Pagination3519-22
Date Published2013 Jun 15
Abstract

Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent.

DOI10.1002/gcc.22099
Alternate JournalBioorg. Med. Chem. Lett.