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New azole antagonists with high affinity for the P2Y(1) receptor.
|Title||New azole antagonists with high affinity for the P2Y(1) receptor.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Ruel R, L'heureux A, Thibeault C, Daris J-P, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PYS|
|Journal||Bioorganic & medicinal chemistry letters|
|Date Published||2013 Jun 15|
Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chain SAR of the more potent thiadiazole ring system which leads to thiadiazole 4c as a new antiplatelet agent.
|Alternate Journal||Bioorg. Med. Chem. Lett.|