Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism.

TitleNeuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism.
Publication TypeJournal Article
Year of Publication2004
AuthorsKates WR, Burnette CP, Eliez S, Strunge LA, Kaplan D, Landa R, Reiss AL, Pearlson GD
JournalThe American journal of psychiatry
Volume161
Issue3
Pagination539-46
Date Published2004 Mar
Abstract

The broader autism phenotype includes relatives of individuals with autism who display social and language deficits that are qualitatively similar to those of autism but less severe. In previous studies of monozygotic twins discordant for autism, more than 75% of the twins without autism displayed the broader phenotype. Differences in neuroanatomy between discordant monozygotic twins might be associated with the narrow and broader behavioral phenotypes. The authors examined the relationship of twin pair differences in clinical phenotype to differences in neuroanatomic phenotype.

Alternate JournalAm J Psychiatry