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Neural stem cells reduce brain injury after unilateral carotid ligation.
|Title||Neural stem cells reduce brain injury after unilateral carotid ligation.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Comi AM, Cho E, Mulholland JD, Hooper A, Li Q, Qu Y, Gary DS, McDonald JW, Johnston MV|
|Date Published||2008 Feb|
Neonatal stroke presents with seizures and results in neurologic morbidity, including epilepsy, hemiparesis, and cognitive deficits. Stem cell-based therapy offers a possible therapeutic strategy for neonatal stroke. We developed an immature mouse model of stroke with acute seizures and ischemic brain injury. Postnatal day 12 CD1 mice received right-sided carotid ligation. Two or 7 days after ligation, mice received an intrastriatal injection of B5 embryonic stem cell-derived neural stem cells. Four weeks after ligation, hemispheric brain atrophy was measured. Pups receiving stem cells 2 days after ligation had less severe hemispheric brain atrophy compared with either noninjected or vehicle-injected ligated controls. Transplanted cells survived, but 3 out of 10 pups injected with stem cells developed local tumors. No difference in hemispheric brain atrophy was seen in mice injected with stem cells 7 days after ligation. Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern.
|Alternate Journal||Pediatr. Neurol.|