Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.

TitleNeonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury.
Publication TypeJournal Article
Year of Publication2010
AuthorsAlbéri L, Chi Z, Kadam SD, Mulholland JD, Dawson VL, Gaiano N, Comi AM
JournalStroke; a journal of cerebral circulation
Volume41
Issue10 Suppl
PaginationS64-71
Date Published2010 Oct
Abstract

Notch receptors (1-4) are membrane proteins that, on ligand stilumation, release their cytoplasmic domains to serve as transcription factors. Notch-2 promotes proliferation both during development and cancer, but its role in response to ischemic injury is less well understood. The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke and to investigate its functional relevance.

DOI10.1097/CCM.0b013e31825457b8
Alternate JournalStroke