Multiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.

TitleMultiparametric MRI correlates of sensorimotor function in the spinal cord in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2013
AuthorsOh J, Zackowski K, Chen M, Newsome S, Saidha S, Smith SA, Diener-West M, Prince J, Jones CK, van Zijl PCM, Calabresi PA, Reich DS
JournalMultiple sclerosis (Houndmills, Basingstoke, England)
Volume19
Issue4
Pagination427-35
Date Published2013 Apr
Abstract

Spinal cord (SC) pathology is a major contributor to clinical disability in multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI), specifically SC-MRI lesion load measures that include lesion count and volume, demonstrate only a modest relationship with the clinical status of MS patients. Although SC cross-sectional area (CSA) correlates better with clinical dysfunction than MRI lesion count, SC atrophy likely signifies irreversible tissue loss. Using quantitative MRI indices sensitive to early and late microstructural changes in the spinal cord, we searched for the presence of better correlations between MRI measures and clinical status in MS.

DOI10.3174/ajnr.A3505
Alternate JournalMult. Scler.