News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability.
|Title||Multichannel scan surface plasmon resonance biochip with stationary optics and baseline updating capability.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Wang C, Liu R, Zhang W, Wang Y, Xu K, Yue Z, Liu G|
|Journal||Journal of biomedical optics|
|Date Published||2013 Nov 1|
An on-chip spectral surface plasmon resonance (SPR) biosensor with three parallel channels has been built for biomolecule detections. It is capable of updating intensity baselines to suppress errors induced by light source instability. In order to minimize structure and reduce positional regression uncertainty, the scan operations are achieved by timely changing optical media instead of conventional mechanical scan. The detection results of human immunoglobulin G (hIgG) demonstrated that the baseline updating improves the limitation of detection of hIgG concentration from ~86.1 to ~17.4 ng/mL.
|Alternate Journal||J Biomed Opt|