News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo.
|Title||Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Weber ML, Chen C, Li Y, Farooqui M, Nguyen J, Poonawala T, Hebbel RP, Gupta K|
|Journal||British journal of anaesthesia|
|Date Published||2013 Dec|
/st> Pain and renal dysfunction occur in sickle cell disease. Morphine used to treat pain also co-activates platelet-derived growth factor receptor-β (PDGFR-β), which can adversely affect renal disease. We examined the influence of morphine in mesangial cells in vitro and in mouse kidneys in vivo.
|Alternate Journal||Br J Anaesth|