Morphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo.

TitleMorphine stimulates platelet-derived growth factor receptor-β signalling in mesangial cells in vitro and transgenic sickle mouse kidney in vivo.
Publication TypeJournal Article
Year of Publication2013
AuthorsWeber ML, Chen C, Li Y, Farooqui M, Nguyen J, Poonawala T, Hebbel RP, Gupta K
JournalBritish journal of anaesthesia
Volume111
Issue6
Pagination1004-12
Date Published2013 Dec
Abstract

/st> Pain and renal dysfunction occur in sickle cell disease. Morphine used to treat pain also co-activates platelet-derived growth factor receptor-β (PDGFR-β), which can adversely affect renal disease. We examined the influence of morphine in mesangial cells in vitro and in mouse kidneys in vivo.

DOI10.1371/journal.pone.0067679
Alternate JournalBr J Anaesth