Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.

TitleModulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhou X, Luo Y-C, Ji W-J, Zhang L, Dong Y, Ge L, Lu R-Y, Sun H-Y, Guo Z-Z, Yang G-H, Jiang T-M, Li Y-M
JournalPloS one
Volume8
Issue9
Paginatione74390
Date Published2013
Abstract

Emerging evidence shows that anti-inflammatory strategies targeting inflammatory monocyte subset could reduce excessive inflammation and improve cardiovascular outcomes. Functional expression of voltage-gated sodium channels (VGSCs) have been demonstrated in monocytes and macrophages. We hypothesized that mononuclear phagocyte VGSCs are a target for monocyte/macrophage phenotypic switch, and liposome mediated inhibition of mononuclear phagocyte VGSC may attenuate myocardial ischemia/reperfusion (I/R) injury and improve post-infarction left ventricular remodeling.

DOI10.1155/2013/361906
Alternate JournalPLoS ONE