Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese lynch syndrome families.

TitleMismatch repair gene mutation analysis and colonoscopy surveillance in Chinese lynch syndrome families.
Publication TypeJournal Article
Year of Publication2013
AuthorsFu L, Sheng J-Q, Li X-O, Jin P, Mu H, Han M, Huang J-S, Sun Z-Q, Li A-Q, Wu Z-T, Li S-R
JournalCellular oncology (Dordrecht)
Volume36
Issue3
Pagination225-31
Date Published2013 Jun
Abstract

Lynch syndrome (or HNPCC) is a colorectal cancer syndrome caused by germline mutations in either one of the DNA mismatch repair (MMR) genes hMLH1, hMSH2, hMSH6 or hPMS2. Mutations in hMLH1 and hMSH2 are most prevalent. Here we aimed to determine the cancer risk of MMR gene mutation carriers and, in addition, the efficacy of colonoscopy surveillance in Chinese Lynch syndrome family members with and without MMR gene mutations.

DOI10.1371/journal.pone.0081430
Alternate JournalCell Oncol (Dordr)