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Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese lynch syndrome families.
|Title||Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese lynch syndrome families.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Fu L, Sheng J-Q, Li X-O, Jin P, Mu H, Han M, Huang J-S, Sun Z-Q, Li A-Q, Wu Z-T, Li S-R|
|Journal||Cellular oncology (Dordrecht)|
|Date Published||2013 Jun|
Lynch syndrome (or HNPCC) is a colorectal cancer syndrome caused by germline mutations in either one of the DNA mismatch repair (MMR) genes hMLH1, hMSH2, hMSH6 or hPMS2. Mutations in hMLH1 and hMSH2 are most prevalent. Here we aimed to determine the cancer risk of MMR gene mutation carriers and, in addition, the efficacy of colonoscopy surveillance in Chinese Lynch syndrome family members with and without MMR gene mutations.
|Alternate Journal||Cell Oncol (Dordr)|