MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways.

TitleMicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X-J, Luo X-Q, Han B-W, Duan F-T, Wei P-P, Chen Y-Q
JournalBritish journal of cancer
Volume109
Issue8
Pagination2189-98
Date Published2013 Oct 15
Abstract

MicroRNAs alter multiple cell processes and thus influence tumour carcinogenesis and progression. MiR-100 and miR-99a have been reported to be aberrantly expressed in acute leukaemia. In this study, we focused on their functions in acute lymphoblastic leukaemia (ALL) and the molecular networks in which they are involved.

DOI10.3402/iee.v3i0.21356
Alternate JournalBr. J. Cancer