Methotrexate for induction of remission in refractory Crohn's disease.

TitleMethotrexate for induction of remission in refractory Crohn's disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsMcDonald JW, Tsoulis DJ, Macdonald JK, Feagan BG
JournalThe Cochrane database of systematic reviews
Volume12
PaginationCD003459
Date Published2012
Abstract

Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to its evaluation in patients with refractory Crohn's disease. Methotrexate has been studied for induction of remission of refractory Crohn's disease and has become the principal alternative to azathioprine or 6-mercaptopurine therapy. This systematic review is an update of a previously published Cochrane review.

DOI10.1016/j.maturitas.2013.03.002
Alternate JournalCochrane Database Syst Rev