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Methotrexate for induction of remission in refractory Crohn's disease.
|Title||Methotrexate for induction of remission in refractory Crohn's disease.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||McDonald JW, Tsoulis DJ, Macdonald JK, Feagan BG|
|Journal||The Cochrane database of systematic reviews|
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to its evaluation in patients with refractory Crohn's disease. Methotrexate has been studied for induction of remission of refractory Crohn's disease and has become the principal alternative to azathioprine or 6-mercaptopurine therapy. This systematic review is an update of a previously published Cochrane review.
|Alternate Journal||Cochrane Database Syst Rev|