A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

TitleA meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Publication TypeJournal Article
Year of Publication2013
AuthorsMonda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MCY, Adeyemo AA, Allison MA, Bielak LF et al.
Corporate AuthorsNABEC Consortium, UKBEC Consortium, BioBank Japan Project, AGEN Consortium
JournalNature genetics
Volume45
Issue6
Pagination690-6
Date Published2013 Jun
Abstract

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

DOI10.1039/c3an00931a
Alternate JournalNat. Genet.