Measurement of T1 and T2 in the cervical spinal cord at 3 tesla.

TitleMeasurement of T1 and T2 in the cervical spinal cord at 3 tesla.
Publication TypeJournal Article
Year of Publication2008
AuthorsSmith SA, Edden RAE, Farrell JAD, Barker PB, van Zijl PCM
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Date Published2008 Jul

T(1) and T(2) were measured for white matter (WM) and gray matter (GM) in the human cervical spinal cord at 3T. T(1) values were calculated using an inversion-recovery (IR) and B(1)-corrected double flip angle gradient echo (GRE) and show significant differences (p = 0.002) between WM (IR = 876 +/- 27 ms, GRE = 838 +/- 54 ms) and GM (IR = 973 +/- 33 ms, GRE = 994 +/- 54 ms). IR showed significant difference between lateral and dorsal column WM (863 +/- 23 ms and 899 +/- 18 ms, respectively, p = 0.01) but GRE did not (p = 0.40). There was no significant difference (p = 0.31) in T(2) between WM (73 +/- 6 ms) and GM (76 +/- 3 ms) or between lateral and dorsal columns (lateral: 73 +/- 6 ms, dorsal: 72 +/- 7 ms, p = 0.59). WM relaxation times were similar to brain structures with very dense fiber packing (e.g., corpus callosum), while GM values resembled deep GM in brain. Optimized sequence parameters for maximal contrast between WM and GM, and between WM and cerebrospinal fluid (CSF) were derived. Since the spinal cord has rostral-caudal symmetry, we expect these findings to be applicable to the whole cord.

Alternate JournalMagn Reson Med