Mammographic density and breast cancer: a comparison of related and unrelated controls in the Breast Cancer Family Registry.

TitleMammographic density and breast cancer: a comparison of related and unrelated controls in the Breast Cancer Family Registry.
Publication TypeJournal Article
Year of Publication2013
AuthorsLinton L, Martin LJ, Li Q, Huszti E, Minkin S, John EM, Rommens J, Paterson AD, Boyd NF
JournalBreast cancer research : BCR
Volume15
Issue3
PaginationR43
Date Published2013 May 25
Abstract

Percent mammographic density (PMD) is a strong and highly heritable risk factor for breast cancer. Studies of the role of PMD in familial breast cancer may require controls, such as the sisters of cases, selected from the same 'risk set' as the cases. The use of sister controls would allow control for factors that have been shown to influence risk of breast cancer such as race/ethnicity, socioeconomic status and a family history of breast cancer, but may introduce 'overmatching' and attenuate case-control differences in PMD.

DOI10.1039/c3cc42962h
Alternate JournalBreast Cancer Res.