Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.

TitleLysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.
Publication TypeJournal Article
Year of Publication2013
AuthorsGillner DM, Becker DP, Holz RC
JournalJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Volume18
Issue2
Pagination155-63
Date Published2013 Feb
Abstract

In this review, we summarize the recent literature on dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure-function studies that provide insight into the catalytic mechanism. Crystallographic data have also provided insight into residues that might be involved in substrate and hence inhibitor recognition and binding. These data have led to the design and synthesis of several new DapE inhibitors, which are described along with what is known about how inhibitors interact with the active site of DapE enzymes, including the efficacy of a moderately strong DapE inhibitor.

DOI10.1155/2013/795103
Alternate JournalJ. Biol. Inorg. Chem.