News & Updates
Search Research Content
Resource Finder at Kennedy Krieger Institute
A free resource that provides access to information and support for individuals and families living with developmental disabilities.
Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.
|Title||Lysine biosynthesis in bacteria: a metallodesuccinylase as a potential antimicrobial target.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Gillner DM, Becker DP, Holz RC|
|Journal||Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry|
|Date Published||2013 Feb|
In this review, we summarize the recent literature on dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure-function studies that provide insight into the catalytic mechanism. Crystallographic data have also provided insight into residues that might be involved in substrate and hence inhibitor recognition and binding. These data have led to the design and synthesis of several new DapE inhibitors, which are described along with what is known about how inhibitors interact with the active site of DapE enzymes, including the efficacy of a moderately strong DapE inhibitor.
|Alternate Journal||J. Biol. Inorg. Chem.|