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Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: regioselective synthesis of multisubstituted 1,2-dihydropyridines.
|Title||Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: regioselective synthesis of multisubstituted 1,2-dihydropyridines.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Shao Y, Zhu K, Qin Z, Li E, Li Y|
|Journal||The Journal of organic chemistry|
|Date Published||2013 Jun 7|
A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.
|Alternate Journal||J. Org. Chem.|