Lewis acid-catalyzed cyclization of enaminones with propargylic alcohols: regioselective synthesis of multisubstituted 1,2-dihydropyridines.

TitleLewis acid-catalyzed cyclization of enaminones with propargylic alcohols: regioselective synthesis of multisubstituted 1,2-dihydropyridines.
Publication TypeJournal Article
Year of Publication2013
AuthorsShao Y, Zhu K, Qin Z, Li E, Li Y
JournalThe Journal of organic chemistry
Volume78
Issue11
Pagination5731-6
Date Published2013 Jun 7
Abstract

A highly efficient BF3·Et2O-catalyzed cascade reaction of enaminones with propargylic alcohols under mild reaction conditions has been developed. This methodology offers regioselective access to multisubstituted 1,2-dihydropyridines in good to excellent yields.

DOI10.1093/infdis/jit410
Alternate JournalJ. Org. Chem.