Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer.

TitleLamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi L, Du Y, Kong X, Li Z, Jia Z, Cui J, Gao J, Wang G, Xie K
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume19
Issue17
Pagination4651-61
Date Published2013 Sep 1
Abstract

Betulinic acid, a naturally occurring pentacyclic triterpenoid, exhibits potent antitumor activities, whereas the underlying mechanisms remain unclear. In the current study, we sought to determine the role and regulation of lamin B1 expression in human pancreatic cancer pathogenesis and betulinic acid-based therapy.

DOI10.1088/0957-4484/24/31/315203
Alternate JournalClin. Cancer Res.