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Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer.
|Title||Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li L, Du Y, Kong X, Li Z, Jia Z, Cui J, Gao J, Wang G, Xie K|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2013 Sep 1|
Betulinic acid, a naturally occurring pentacyclic triterpenoid, exhibits potent antitumor activities, whereas the underlying mechanisms remain unclear. In the current study, we sought to determine the role and regulation of lamin B1 expression in human pancreatic cancer pathogenesis and betulinic acid-based therapy.
|Alternate Journal||Clin. Cancer Res.|