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L-Proline catalyzed reaction of N-confused porphyrin and active methylene compounds.
|Title||L-Proline catalyzed reaction of N-confused porphyrin and active methylene compounds.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Liu B, Li X, Zhang J, Chmielewski PJ|
|Journal||Organic & biomolecular chemistry|
|Date Published||2013 Aug 7|
Active methylene compounds such as acetone, butanone, cyclopentanone, nitromethane, malononitrile, ethyl 2-cyanoacetate, diethyl malonate, and ethyl acetylacetate react with the C3 position of N-confused porphyrin in the presence of L-proline in refluxing THF-EtOH affording a variety of N-confused porphyrin derivatives in moderate yield. L-Proline catalyzes the reaction facilitating the formation of the carbanion derived from an active methylene compound simultaneously delivering protons to the N-confused porphyrin. Both processes are key factors of this reaction.
|Alternate Journal||Org. Biomol. Chem.|