Kinase AKT controls innate immune cell development and function.

TitleKinase AKT controls innate immune cell development and function.
Publication TypeJournal Article
Year of Publication2013
AuthorsZhang Y, Wang X, Yang H, Liu H, Lu Y, Han L, Liu G
JournalImmunology
Volume140
Issue2
Pagination143-52
Date Published2013 Oct
Abstract

The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity-related diseases, mainly through the mammalian target of rapamycin-dependent or -independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.

DOI10.1371/journal.pone.0076782
Alternate JournalImmunology