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Japonicone A suppresses growth of Burkitt lymphoma cells through its effect on NF-κB.
|Title||Japonicone A suppresses growth of Burkitt lymphoma cells through its effect on NF-κB.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li X, Yang X, Liu Y, Gong N, Yao W, Chen P, Qin J, Jin H, Li J, Chu R, Shan L, Zhang R, Zhang W, Wang H|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2013 Jun 1|
NF-κB, a transcriptional regulator of diverse genes involved in cell survival, proliferation, adhesion, and apoptosis, has been implicated in various malignancies. We discovered a potent natural NF-κB inhibitor, Japonicone A, from the traditional herb Inula japonica Thunb, evaluated its preclinical pharmacology and therapeutic activity, and investigated the underlying mechanisms of action for its antitumor activity.
|Alternate Journal||Clin. Cancer Res.|