Japonicone A suppresses growth of Burkitt lymphoma cells through its effect on NF-κB.

TitleJaponicone A suppresses growth of Burkitt lymphoma cells through its effect on NF-κB.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi X, Yang X, Liu Y, Gong N, Yao W, Chen P, Qin J, Jin H, Li J, Chu R, Shan L, Zhang R, Zhang W, Wang H
JournalClinical cancer research : an official journal of the American Association for Cancer Research
Volume19
Issue11
Pagination2917-28
Date Published2013 Jun 1
Abstract

NF-κB, a transcriptional regulator of diverse genes involved in cell survival, proliferation, adhesion, and apoptosis, has been implicated in various malignancies. We discovered a potent natural NF-κB inhibitor, Japonicone A, from the traditional herb Inula japonica Thunb, evaluated its preclinical pharmacology and therapeutic activity, and investigated the underlying mechanisms of action for its antitumor activity.

DOI10.1371/journal.pone.0062087
Alternate JournalClin. Cancer Res.